Universal Viewer / IIIF / Image Server errors on upgrade to v4

As best as I can see, the 6 prior posts connected to my issue do not solve it.

After upgrading Omeka S to 4.2.1, UV to 3.6.16-p4.4.4, Image Server to 3.6.25, and IIIF Server to 3.6.33, I get an error on pages with a UV embedded : Unable to load manifest

Auto-tiling has been turned on and In looking at the Image Server configuration, I see errors that might be pertinent.

For Image Server:
The directory "tile" is not writable. Check permissions.
The directory "tile/cache" is not writable. Check permissions.

For IIIF Server:
Manifest cache is enabled but directory "files/iiif" is not writable.

I cannot find a tile directory nor a files/iiif directory on the server anywhere using the find command.

[Apologies for the serial editing – I sent this before completing]

This is an install that’s been around a while, so if it matters we used to use Derivative Images.